Human iPSCs From Older Adults Carry More mtDNA Mutations (IMAGE)

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Human iPSCs From Older Adults Carry More mtDNA Mutations

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This visual abstract depicts Mitalipov and colleagues findings that human iPSCs derived from older adults carry more mitochondrial DNA mutations than those derived from younger individuals. Defects in metabolic function caused by mtDNA mutations suggest careful screening of hiPSC clones for mutational load before clinical application.

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Mitalipov et al./Cell Stem Cell 2016

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