Aberrant Differentiation (IMAGE)

Tokyo Medical and Dental University

Aberrant Differentiation

Caption

A. ISCs undergo self-renewal and have the capacity to produce more differentiated epithelial cells, such as immature secretory epithelial cells. The balance between self-renewal and differentiation is strictly maintained in ISCs. B. In Irf2-/- mice, augmented IFN signaling causes aberrant differentiation of ISCs into immature secretory epithelial cells, that causes ISC reduction.

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Department of Biodefense Research,TMDU

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