A schematic model shows the effects of EEF1AKMT4 and eEF1A2 on regulating ribosomal protein synthesis. (IMAGE)
Caption
EEF1AKMT4 trimethylates eEF1A2 at K36 and fuels its GTPase activity. Elevated eEF1A2 enzyme activity promotes the protein output of several oncogenic growth signals including AKT and ERK. Overall, upregulated eEF1A2 expression together with the fuel of EEF1AKMT4 promotes the progression of GBC and LN metastasis.
Credit
Genes & Diseases
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