PTBP1 associated chimeric RNAs. (IMAGE)

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PTBP1 associated chimeric RNAs.

Caption

(A) OS and TS isoforms were among 14 chimeras found only in COVID-19 whole blood and PTBP1 knockdown. (B) Mosaic plot for TS detection in COVID-19 patients by disease status. (C) Mosaic plot for OS detection by disease status. (D) Alignment of chimeric junction sequences to their parental genes for all detected PTBP1-dependent chimeras around the TS/OS locus. (E) PTBP1 RNA binding motifs proximal to the terminal SCO2 exon. (F) Gene expression of interferon (IFN) signaling and chimeric parental genes in CD34 primary cells treated with erythropoietin (EPO) (control vs. PTBP1 knockdown). PTBP1, polypyrimidine tract binding protein 1; SCO2, synthesis of cytochrome c oxidase 2; OS, ODF3B (ciliary microtubule associated protein 1B)–SCO2; TS, TYMP (thymidine phosphorylase)-SCO2.

Credit

Genes & Diseases

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