ATP regulates cytosolic viscosity in axons (IMAGE)

Okinawa Institute of Science and Technology (OIST) Graduate University

ATP regulates cytosolic viscosity in axons

Caption

ATP has been found to regulate cytosolic viscosity and thereby protein aggregation, which can lead to synaptic dysfunction and neurodegeneration. NMN (nicotinamide mononucleotide) is a precursor to NADH (nicotinamide adenine dinucleotide), which in turn is used by the mitochondria to synthesize ATP. By increasing the availability of NMN, cytosolic viscosity may therefore be reduced.

Credit

Laurent Guillaud (OIST)

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CC BY

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