Relationship between a new CGM-derived index and blood glucose control ability (IMAGE)
Caption
Simulations using mathematical models further supported why AC_Var — a CGM-derived index — could detect declines in glycemic control earlier than traditional indicators such as fasting glucose. In their previous study, the researchers found that as diabetes develops, glucose control ability (insulin secretion, sensitivity and clearance from the bloodstream) first moves upward (as depicted along the red surface in the left diagram) before eventually declining (blue line in the left diagram). During this phase, traditional diabetes markers, such as fasting blood glucose, remain unchanged (black line in the right diagram), while AC_Var increases (green line in the right diagram), signaling early impairment. This suggests that AC_Var can detect declining glucose regulation before standard diagnostic indicators change.
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Shinya Kuroda, The University of Tokyo
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