1. DHX36 deficiency results in abnormal chromatin conformation and decreased chromatin openness in mouse oocytes. (IMAGE)

Science China Press

1. DHX36 deficiency results in abnormal chromatin conformation and decreased chromatin openness in mouse oocytes.

Caption

(a) Fluorescence images showing the chromatin in FGO stained with DAPI. Scale bar, 20 μm. Yellow triangles indicate DAPI-dense heterochromatin foci and the red triangles denote the nucleoli or NLBs. (b) Immunofluorescence images illustrating HP1α signal across chromatin of WT and CKO FGO. Yellow triangles indicate DAPI-dense heterochromatin foci. Scale bar, 20 μm. (c) Heatmaps showing peak gain and loss in WT and CKO FGO, detected by ATAC-seq. (d) General chromatin accessibility ranging from TSS to transcription end site (TES) of WT and CKO GO/FGO. (e) Chromatin accessibility of rDNA in WT and CKO GO/FGO. (f) Unique motif enriched in WT and CKO GO/FGO.

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