Cachexia brain regions (IMAGE)

Cold Spring Harbor Laboratory

Cachexia brain regions

Caption

The neuro-immune circuit Janowitz and Kepecs identified involves three key brain regions: the area postrema (ArP), which triggers nausea and vomiting; the parabrachial nucleus (PBN), which plays a role in appetite regulation; and the substantia nigra pars reticulata (SNpr), which can lower natural dopamine levels. Here, PBN neurons receive input from the ArP (red) and send projections to the SNpr (blue).

Credit

Kepecs lab, WashU Medicine / Janowitz lab, CSHL

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