Image 2 (IMAGE)
Caption
Effect of ligustroside on (A-B) the MAPK and PKA/CREB signaling pathways as well as (C) nuclear protein levels of MITF, β-catenin, and p-CREB/CREB in α-MSH-stimulated B16F10 murine melanoma cells. Cells were treated with ligustroside for 24 h and the changes in protein expression were quantified by Western blot. Values were given as relative percentage of the control group. β-actin or Lamin B1 was used as a housekeeping protein. *P<0.05, **P<0.001 vs. control cells, #P<0.05 vs. the blank group.
Credit
Xian-Rong Zhou, Fatih Karadeniz, Jung Hwan Oh, Youngwan Seo, Chang-Suk Kong
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