Figure 1. Flexible Multisensory Processing Based on Behavioral State (IMAGE)
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(A) Mice are trained to respond to external audiovisual cues by making decisions to receive a water reward while avoiding a mild air puff. When both auditory and visual stimuli are presented together, stationary mice prioritize auditory cues, whereas running mice rely more on visual information for decision-making.
(B) Calcium imaging was used to analyze neuronal activity in the posterior parietal cortex (PPC) in response to auditory, visual, and combined audiovisual stimuli.
(C) A response map showing neural activation in the PPC of a mouse during sensory stimulation. Activated neurons showed increased fluorescence (white to red). Auditory responses were notably reduced when the mouse was running compared to when it was stationary, highlighting the state-dependent nature of sensory integration.
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Institute for Basic Science
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