Figure 2. Mechanism of Flexible Multisensory Processing (IMAGE)
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When the mouse is stationary, auditory signals suppress visual-processing neurons in the posterior parietal cortex (PPC), leading to auditory-dominant decision-making. However, during running, motor-related signals selectively inhibit the neural pathway transmitting auditory information to the PPC. This reduces auditory interference and enhances visual processing, resulting in visual-dominant decision-making. This dynamic mechanism allows the brain to flexibly integrate audiovisual sensory information, adapting to the behavioral state by prioritizing either auditory or visual cues as needed.
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Institute for Basic Science
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