Identification of NK_scissor_C1 cell-associated drug candidates. (IMAGE)

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Identification of NK_scissor_C1 cell-associated drug candidates.

Caption

(A) Volcano plot of NK_scissor_C1-associated drug priorities. (B) NK_scissor_C1-associated drug usage status. (C) The Veen diagram showing intersections of NK_scissor_C1-associated drug targets with HCC-associated genes. (D) Interaction network of top 10 significant nodes under 8 predictive node importance algorithms. EPC, edge percolated component; MCC, maximal clique centrality; MNC, maximum neighborhood component. (E) 3D structures of the two drug candidates docetaxel and thalidomide. (F) Correlation of NK_scissor_C1 levels with drug sensitivity to docetaxel in the TCGA-HCC dataset. (G) Correlation of NK_scissor_C1 levels with drug sensitivity to docetaxel in the GSE14520 dataset. (H) Correlation of NK_scissor_C1 levels with drug sensitivity to docetaxel in the GSE76427 dataset.

Credit

Genes & Diseases

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