Changes in monocytes/macrophages during CRLM (IMAGE)
Caption
(A) Volcano plot of DEGs in monocytes/macrophages between NC and CRC samples in the GSE164552 dataset. (B) Venn diagrams of common DEGs up- or down-regulated across the six scRNA-seq datasets (NC vs. CRC). (C) Metascape bar graph of functional enrichment analysis results for common DEGs (NC vs. CRC). The top 20 enriched hallmark terms are displayed. (D) Volcano plot of DEGs in monocytes/macrophages between CRC and LM samples in the GSE164552 dataset. (E) Venn diagrams of common DEGs up- or down-regulated across the three scRNA-seq datasets (CRC vs. LM). (F) Metascape bar graph of functional enrichment analysis results for common DEGs (CRC vs. LM). The top 20 enriched hallmark terms are displayed. (G–I) Trajectory analysis of monocytes/macrophages (Wu et al), including color-coded subsets (G), tissue types (H), and gene expression levels (I). (J) Heatmap of GSVA (Gene Set Variation Analysis) scores of 50 hallmark pathways for different monocyte/macrophage subsets (Wu et al). CRC, colorectal cancer; CRLM, colorectal cancer liver metastases; NC, normal colorectum (adjacent colorectum); DEGs, differentially expressed genes; LM, liver metastases.
Credit
Genes & Diseases
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND