Figure 2. Synaptic Connections Between Stimulus-Specific Neuronal Populations in the ACC and MD (IMAGE)
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(a) An image showing the expression of dual-eGRASP in the anterior cingulate cortex (ACC). The middle image displays neurons activated by an itch-inducing stimulus. The right image displays neurons activated by a pain-inducing stimulus.
(b) An image of dendritic spines in the ACC, where dual-eGRASP is expressed following pain and itch stimulation. Cyan-GRASP (cyan signals) represents input from mediodorsal thalamus (MD) neurons activated by an itch-inducing stimulus. Yellow-GRASP (yellow signals) represents input from MD neurons activated by a pain-inducing stimulus.
Analysis of the relative proportions of dual-eGRASP signals revealed that synaptic inputs to ACC neurons are predetermined by the presynaptic neurons in the MD, indicating that the neuronal connectivity is established in advance based on the stimulus-specific neuronal populations in the MD.
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Institute for Basic Science
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