Schematic representation summarising MASLD-associated long non-coding RNAs (lncRNAs) and their relevant targets in hepatocytes (IMAGE)
Caption
Schematic representation summarising MASLD-associated long non-coding RNAs (lncRNAs) and their relevant targets in hepatocytes: human leukocyte antigen (HLA) complex group 18 (HCG18), nuclear enriched abundant transcript 1 (NEAT1), growth arrest specific 5 (Gas5), H19 imprinted maternally expressed transcript (H19), homeobox transcript antisense RNA (HOTAIR), maternally expressed gene 3 (MEG3), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), triosephosphate isomerase 1 (TPI1), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), forkhead box O1 (FOXO1), phosphoenolpyruvate carboxykinase 1 (PCK1), glucose-6-phosphatase catalytic subunit (G6PC), adenosine monophosphate (AMP)-activated protein kinase (AMPK) catalytic subunit, Jun proto-oncogene (C-Jun), mammalian target of rapamycin complex 1 (mTORC1), neurogenic locus notch homolog protein 2 (Notch2), polypyrimidine tract-binding protein 1 (PTBP1), peroxisome proliferator activated receptor gamma (PPARγ), Rho-kinase 1 (ROCK1), sirtuin 6 (SIRT6), sterol regulatory element binding protein 2 (SREBP2), peroxisome proliferator activated receptor alpha (PPARα), aryl hydrocarbon receptor nuclear translocator (ARNT), polycomb repressive complex 2 subunit enhancer of zeste homologue 2 (EZH2), sterol regulatory element binding protein 1c (SREBP1c), glucose transporter 2 (GLUT2). LncRNAs in blue boxes are upregulated in MASLD whereas those in red boxes are downregulated. MASLD, metabolic dysfunction-associated steatotic liver disease.
Credit
By Henry Wade, Kaichao Pan, Bingrui Zhang, Wenhua Zheng, Qiaozhu Su
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CC BY-NC