A schematic representation summarising MASLD-associated long non-coding RNAs (lncRNAs) and their associated relevant targets in hepatic stellate cells (HSCs) (IMAGE)
Caption
A schematic representation summarising MASLD-associated long non-coding RNAs (lncRNAs) and their associated relevant targets in hepatic stellate cells (HSCs): plasmacytoma variant translocation 1 (PVT1), homeobox transcript antisense RNA (HOTAIR), alu-mediated P21 transcriptional regulator (APTR), small nucleolar RNA host gene 7 (SNHG7), growth arrest specific 5 (Gas5), maternally expressed gene 3 (MEG3), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), DNA (cytosine-5-)-methyltransferase (DNMT), patched 1 gene (PTCH1), mouse double minute 2 homologue (MDM2) proto-oncogene, phosphatase and tensin homolog (Pten), nuclear factor erythroid 2-like basic leucine zipper transcription factor 2 (Nrf2), reactive oxygen species (ROS), nuclear factor-κB (NF-κB), toll-like receptor 4 (TLR4). LncRNAs in blue boxes are upregulated in MASLD whereas those in red boxes are downregulated. MASLD, metabolic dysfunction-associated steatotic liver disease.
Credit
By Henry Wade, Kaichao Pan, Bingrui Zhang, Wenhua Zheng, Qiaozhu Su
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CC BY-NC