fig 2 (IMAGE)
Caption
PIK3CA helical domain mutation rewires cell signaling. Helical domain mutation of p110α gains interaction with IRS1 and loses interaction with p85α/β. p110α with helical domain mutation is brought to cell membrane by IRS1 independent of p85, where it converts PIP2 to PIP3. The released p85β but not p85α translocates into the nucleus and stabilizes EZH1/2 by recruiting deubiquitylating enzyme USP7. EZH1/2, enhancer of zeste homolog 1/2; IRS1, insulin receptor substrate 1; PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; PIP2, phosphatidylinositol (4,5)-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate; RTK, receptor tyrosine kinase; USP7, ubiquitin-specific-processing protease 7.
Image link: https://ars.els-cdn.com/content/image/1-s2.0-S2352304224002277-gr2_lrg.jpg
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