Fig. 3 (IMAGE)

Osaka University

Fig. 3

Caption

A hypothetical model of the detailed mechanism of action of tricaprin

Given that beneficial effects of tricaprin were observed in ATGL-knockout mice, these effects are likely to be ATGL-independent. Capric acid (C10:0), the fatty-acid component of tricaprin, may play a key role in altering both substrates and enzymes involved in intracellular TG hydrolysis. Capric acid (C10:0) is incorporated into the TG pool to form chimeric TG with long-chain fatty acid. TG with C10:0 is preferentially hydrolysed by enzymes (i.e. carboxy-esterase) possessing lipolytic activities other than ATGL.
Abbreviations: ATGL, adipose triglyceride lipase; C10:0, capric acid; LCFA, long-chain fatty acid; TG, triglyceride; TGCV, triglyceride deposit cardiomyovasculopathy.

Credit

2025 Hirano et al., Long-term survival and durable recover of heart failure in patients with triglyceride deposit cardiomyovasculopathy treated with tricaprin. Nature Cardiovascular Research

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