Schematic diagram of Mendelian randomisation study designs in metabolic dysfunction-associated steatotic liver disease. (IMAGE)
Caption
This figure illustrates two distinct approaches on genetic variants selection. The statistically driven approach, often termed as ‘genome-wide’ or ‘polygenic’ Mendelian randomisation, employs all genetic variants associated with the exposure across the entire genome. The biologically driven approach, typically referred to as ‘drug-target’ Mendelian randomisation, selectively uses genetic variants from a single gene region with a known biological link to the exposure. The selection of exposures could be based on various phenotypes that reflects a measure of pharmacological perturbation of drug target, including gene expression, protein expression at disease relevant tissue(s), downstream biomarkers and clinical outcomes. LPL, lipoprotein lipase.
Credit
By Shan Luo, Ming-Hua Zheng, Vincent Wai-Sun Wong, Shiu Lun Au Yeung
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CC BY-NC