Mechanisms of Mutation-Induced Pathogenesis in sporadic AVMs. (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Mechanisms of Mutation-Induced Pathogenesis in sporadic AVMs.

Caption

KRAS mutated endothelium promotes the occurrence and development of AVMs through a variety of ways, including promoting EndMT, angiogenesis, VEGF signaling pathway and pericyte loss. KRAS mutation in endothelial cells activates the MEK/ERK pathway, but has no direct effect on PI3k. Subsequently, KRAS/BRAF activates the Notch pathway or TGFb/BMP pathway through the MEK/ERK pathway, thereby affecting endothelial cell function. It is worth noting that these mutated endothelial cells also release vesicles that affect normal endothelial cells.

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Dr. Yong Cao and Dr. Jizong Zhao

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