MH3 Λ可靶向并稳定G4，从而上调A5L编码蛋白的示意图 (IMAGE)

Science China Press

MH3 Λ可靶向并稳定G4，从而上调A5L编码蛋白的示意图

Caption

一种在MPXV A5L基因的mRNA中高度保守和稳定的G4，可作为病毒免疫显性蛋白表达的正向调控元件。RNA G4特异性解旋酶DHX36通过解旋G4抑制A5L蛋白表达。相反，MH3 Λ通过特异性靶向G4结构增强了mRNA的稳定性，进而促进了蛋白表达。

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