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fig 2

Caption

Figure 2. Tumor promoting roles of LKB1. LKB1-STRAD-MO25 activity can promote tumorigenesis by increasing reactive oxygen species (ROS) scavenging NADPH. Given that ROS damage tumor cells, increasing NADPH in tumors protects these cells from ROS-mediated damages. LKB1-AMPK signaling can enhance autophagy. Increasing autophagy in tumor cells leads to chemotherapeutic resistance, epithelial–mesenchymal transition (EMT), and invasion. Activating the LKB1-AMPK-mTOR pathway could protect tumor cells from anoikis, which is a form of cell death that occurs when cells detach from the basement membrane. A-769662 is an AMPK agonist that has increased tumorigenesis.

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Genes & Diseases

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