fig 1 (IMAGE)
Caption
Figure 1. Ce6-GFFY prohibits colorectal cancer growth and has little side effects. Agents were injected through the tail vein of the CT26-derived subcutaneous tumor mice model, and the 660 nm, 0.2 W/cm2 laser irradiation (1 min on, 1 min off; 4 cycles) was performed 6 h after the injection. Only a single dose was administered during the entire treatment cycle. (A) Schematic diagram of the PDT strategy. PDT, photodynamic therapy. (B–D) Mice were treated with PBS, GFFY (2.5 mg/kg), Ce6 (2.5 mg/kg), or Ce6-GFFY (5 mg/kg), and tumor tissues were collected (B) and weighed (C) after treatment, and tumor growth curve was analyzed during treatment (D). n = 4. (E) Mice body weight was analyzed during treatment. n = 4. (F) Pathological analysis of hearts, livers, spleens, lungs, and kidneys derived from the indicated agents treated mice using hematoxylin-eosin (H&E) staining. n = 4. “L” in “PBS + L”, “GFFY + L”, “Ce6+L”, “Ce6-GFFY + L”: laser irradiation. Scale bar, 200 μm. Statistical analyses were performed using two-way ANOVA; bars, standard deviation; n.s., not significant; ∗∗∗P < 0.001; ∗∗∗∗P < 0.0001.
Credit
Genes & Diseases
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