aGPCR activation (IMAGE)

University of Chicago

aGPCR activation

Caption

a) Cryo-EM model of Latrophilin3. The transmembrane region (7TM) is embedded in the cell membrane, and the GAIN domain and tethered agonist (TA) are part of the extracellular region. b) Antibodies (sAB) change the configuration of the GAIN domain and activate the receptor. 

Credit

Szymon Kordon

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