Direct and indirect approaches of mAbs antibacterials (IMAGE)
Caption
Illustrative diagram of the two main approaches of the antibacterial therapeutic antibodies. In the direct approach, three possible modes of action can occur; inactivate pathogens and toxins by neutralization, phagocytosis of the bacteria through opsonization, and lysis of the target bacteria by complement activation. In the indirect approach, antibiotics bind to antibodies by a linker, the antibody attaches specifically to its target receptor on the surface of the bacteria where the antibiotic is released, performing its destructive action on the target bacteria.
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Hassan Aboul-Ella
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