Reinforcing loops stabilize transcriptional bursting (IMAGE)
Caption
When a gene is active, the production of RNA and the accumulation of proteins creates a more viscous environment, slowing down the movement of DNA. This allows for longer times of interaction between enhancers and promoters, stabilizing the transcriptional burst. In the inactive state, the DNA moves quickly. This means there is insufficient time for the enhancers and promoters to interact, stabilizing the inactive state.
Credit
Ohishi et al. (2024) Sci. Adv <https://doi.org/10.1126/sciadv.adn0020>
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CC BY-NC