[3] Proof of COVID-19 antiviral effect of EGFR inhibitor(vandetanib) (cell experiments – subjects infected with various COVID-19 mutant strains) (IMAGE)
Caption
▲qRT-PCR test results using infection reacted for 44 hours in cell culture medium mixed with vandetanib(10 μM) → The amount of RNA in the virus released outside the cell decreases in a range of 1,000–fold to 100,000-fold.
▲The culture medium of infected cells mixed with vandetanib(1, 5, 10 μM) and reacted for 44 hours was treated with new cells for eight hours, and then COVID-19 virus-specific antibody staining was performed (infection of new viral progeny by vandetanib treatment production rate analysis) → Infected cell count (FFU) analysis results using antibody staining analysis equipment → In the case of untreated vandetanib, many blue dots (infected cells) are visible. In the case of treatment (10 μM), the blue dot is reduced to the point where it is barely visible.
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Korea Research Institute of Chemical Technology(KRICT)
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