[1] Schematic diagram showing the impact of the COVID-19 virus on “mitochondrial and EGFR receptor protein modification and function regulation” of human host cells (IMAGE)
Caption
A schematic diagram showing the significant contribution of SCoV2-induced altered mitochondrial dynamics and mitochondrial EGFR translocation in sustaining viral propagation. First, SCOV2 RNA and nucleocapsid complex increases membrane potential during the early stages of SCoV2 infection. This alteration subsequently promotes mitochondrial elongation. SCoV2 also activates the mitochondrial OXPHOS process, thereby promoting ATP production. Second, SCoV2 activates EGFR-mediated cell survival signaling and subsequently promotes mitochondrial EGFR internalization, which contributes to the maintenance of abnormal mitochondrial bioenergetics. These alterations are physiologically relevant to the maintenance of homoeostasis of SCoV2-infected cells and robust SCoV2 propagation.
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Korea Research Institute of Chemical Technology(KRICT)
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