Mechanism of BRAF Inhibitor Resistance (IMAGE)

National Research Council of Science & Technology

Mechanism of BRAF Inhibitor Resistance

Caption

Melanomas resistant to BRAF inhibitors show increased polyamine biosynthesis, driven by the activation of the oncogene c-Myc. This ultimately leads to increased mitochondrial activity and drug resistance. The study demonstrates that inhibiting polyamine biosynthesis can block this mechanism, overcoming drug resistance.

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Korea Institute of Science and Technology

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