Xin Zhou, PhD (IMAGE)
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“Our findings demonstrate that CAR-NKT cells not only effectively eliminate CD1d-expressing M2-like macrophages within the tumor microenvironment but also stimulate endogenous immune cells,” said Xin Zhou, PhD, the paper’s first author and a UNC Lineberger postdoc. “This dual function—overcoming suppressive immune cells and promoting sustained immune activity—represents a crucial advancement in improving CAR-based therapies for solid tumors and achieving long-term tumor control.”
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UNC Lineberger Comprehensive Cancer Center
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