(IMAGE)

Kumamoto University

Caption

Loss of TRMT10A led to a decrease in the levels of initiator methionine tRNA (tRNAiMet) and a specific glutamine tRNA (tRNAGln). This reduction weakened the initiation of protein synthesis for certain brain genes and made the genetic code for glutamine harder to recognize. As a result, the production of neuron-related proteins was impaired, leading to brain dysfunction.

Credit

Kazuhito Tomizawa and Takeshi Chujo, Kumamoto University

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