Effects of TRMT10A Deficiency on Codon Translation and Brain Function (IMAGE)

Kumamoto University

Effects of TRMT10A Deficiency on Codon Translation and Brain Function

Caption

Loss of TRMT10A led to a decrease in the levels of initiator methionine tRNA (tRNAiMet) and a specific glutamine tRNA (tRNAGln). This reduction weakened the initiation of protein synthesis for certain brain genes and made the genetic code for glutamine harder to recognize. As a result, the production of neuron-related proteins was impaired, leading to brain dysfunction.

Credit

Kazuhito Tomizawa and Takeshi Chujo, Kumamoto University

Usage Restrictions

Only to be used in content reporting on this research. Credit must be given to the creator.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.