Figure 3. Techniques for silencing active synapses (IMAGE)

Institute for Basic Science

Figure 3. Techniques for silencing active synapses

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The As-PaRac1 technique uses blue light to activate RAC1 protein, leading to actin disassembly and dendritic spine shrinkage in the postsynaptic neuron. Similarly, the Cofilin-SuperNova technique employs a cofilin-targeted modified Killer Red protein that produces reactive oxygen species (ROS) upon light exposure, disrupting F-actin assembly and thereby weakening synaptic interactions.

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Institute for Basic Science

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