Caspase-11 drives interleukin-1β (IL-1β) secretion in paws and affects clinical severity of arthritis in mice infected with Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) (IMAGE)

Tokyo Medical and Dental University

Caspase-11 drives interleukin-1β (IL-1β) secretion in paws and affects clinical severity of arthritis in mice infected with Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans)

Caption

Researchers unveil mechanism by which periodontal bacterium A. actinomycetemcomitans exacerbated symptoms of rheumatoid arthritis (RA) conducted various experiments in a mouse model of rheumatoid arthritis (RA). They investigated the molecular-level effects of infection with the periodontal pathogen A. actinomycetemcomitans, and found that caspase-11 plays a key role in the exacerbation of RA, as mice deficient in this protein exhibited much milder symptoms.

Credit

Department of Bacterial Pathogenesis, Infection and Host Response, TMDU

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.