Regions of interest (ROIs) and their classification. (IMAGE)

First Hospital of Jilin University

Regions of interest (ROIs) and their classification.

Caption

Multiplex immunofluorescent images of representative ROIs from each patient are shown (A–C). Regions were classified as either ‘low’ or ‘high’ for hepatitis B virus (HBV) or immune infiltrate, based on the abundance of HBV surface antigen (HBsAg)+ and CD45+ cells, respectively. This categorisation was used for all downstream analysis. In the bottom left of each image, the ROI identifier is labelled. In patient (PT)3, there was extensive HBsAg staining with no HBsAg low regions identified.

Credit

By Amy Cross, James M Harris, Edward Arbe-Barnes, Colin Nixon, Rageshri Dhairyawan, Andrew Hall, Alberto Quaglia, Fadi Issa, Patrick T F Kennedy, Jane A McKeating, Upkar S Gill, Dimitra Peppa

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.