Figure 3. Computational analysis based on modelling and mathematical rigidity theory (IMAGE)

Tokyo Institute of Technology

Figure 3. Computational analysis based on modelling and mathematical rigidity theory

Caption

Computational analysis based on modelling and mathematical rigidity theory identifies activation (allosteric) network pathway (red) propagating through the A2AR GPCR and the differences in the pathways in the A2AR-Gs (left) and A2AR-Go (right) complexes. These pathways play a major role in the control of GPRC activation, the control in activation states, and G protein selectivity.

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Nature Chemical Biology

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