The development of suppressor tRNAs (IMAGE)
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A timeline is pictured showing selected milestones in the suppressor tRNA development. Since the first report on the discovery of ‘nonsense mutation’ and ‘suppressor mutation’ in 1962 (Benzer and Champe, 1962), the next years of basic biology researches gradually demonstrate the mechanism of the suppression of nonsense mutation by suppressor tRNAs (Engelhardt et al., 1965). It was found that all three types of stop codons in eukaryotes could be read through in 1980 (Bienz et al., 1980). Similar results were also reported in mammalian cells in 1982 (Hudziak et al., 1982). The first in vivo suppressor tRNA research by topical administration was conducted in 2000 (Buvoli et al., 2000). Two representative studies about systematic delivery of suppressor tRNA in vivo via Adeno-associated virus (AAV) and lipid nanoparticle (LNP) to treat nonsense-related diseases were reported in 2022 and 2023 (Albers et al., 2023; Wang et al., 2022).
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