Fig. 2 (IMAGE)

Osaka University

Fig. 2

Caption

Splicing of REST is regulated by SRRM4-mediated microexon N insertion, thereby lowering functional REST expression in SCLC/NEPCa. REST_SSO induces the skipping of microexon N insertion by interfering with SRRM4 binding, thereby upregulating functional REST expression.

Credit

2024 Shimojo et al., Splice-switching antisense oligonucleotide controlling tumor suppressor REST is a novel therapeutic medicine for neuroendocrine cancer, Molecular Therapy Nucleic Acids

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