(IMAGE) Chiba University Caption Atherosclerosis is a leading cause of death in patients with WS, a rare genetic disease associated with premature aging. Now, a study by researchers from Japan reveals that the buildup of plaque in the arteries, which can eventually cause a stroke or heart attack, is mostly driven by macrophages in an abnormal pro-inflammatory state. Credit Sudip Kumar Paul from Chiba University Usage Restrictions You are free to share and adapt the material. Attribution to the author is required. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.