Inhibition of aggregation of insulin solution (IMAGE)
Caption
Inhibition of aggregation of insulin solution. i) before heating, ii) after heating without PSPB and iii) after heating with PSPB.
It can be seen that heating causes white turbidity due to aggregation. On the other hand, the addition of PSPB suppresses the cloudiness.
iv) Molecular dynamics (MD) simulations of insulin dimer with model compound (SPB2_BuMA). Snapshot structure of SPB2_BuMA system at 52.0 ns in MD simulation.
These molecules were sandwiched between two insulins (Ins and Ins’), unambiguously demonstrating molecular shielding to inhibit aggregation.
Credit
Kazuaki Matsumura from JAIST.
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