Unfavorable conditions can lead to protein misfolding and aggregate formation (IMAGE)

Japan Advanced Institute of Science and Technology

Unfavorable conditions can lead to protein misfolding and aggregate formation

Caption

Protein stabilization is key to tackling protein aggregation, which is involved in neurodegenerative diseases. Rajan et al. explore molecular mechanisms by which zwitterionic polymers stabilize proteins, highlighting how modifications in hydrophobicity and molecular weight effectively prevent aggregation.

Credit

Kazuaki Matsumura from JAIST.

Usage Restrictions

Cannot be reproduced without permission.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.