Overall structure of the prime editor complex (IMAGE)

School of Science, The University of Tokyo

Overall structure of the prime editor complex

Caption

Surface model of SpCas9–reverse transcriptase–pegRNA–target DNA complex. The prime editor, composed of a SpCas9 and a reverse transcriptase, reverse transcribes template sequence in pegRNA, resulting in incorporation of desired edits to the targeted site in the genome. The RNA–DNA heteroduplex forms along the RuvC nuclease domain of SpCas9.

Credit

Shuto et al 2024

Usage Restrictions

Credit must be given to the creator.

License

CC BY

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