Drug Discovery and Anticancer Effects Demonstrated Using Specific Mutations in Korean Never-Smoking Lung Cancer (IMAGE)

National Research Council of Science & Technology

Drug Discovery and Anticancer Effects Demonstrated Using Specific Mutations in Korean Never-Smoking Lung Cancer

Caption

(Left) Validation of proteins associated with estrogen response using tissue immunostaining, identifying Saracatinib as the most effective drug in inhibiting the expression of related proteins using public bio big data and cross-analyzing its mechanism with genetic expression in Korean never-smoking lung cancer patients to predict positive anticancer effects.
(Right) Selection of cell lines with mutations identical to those found in patients among lung cancer cell lines, treated with Saracatinib alongside a control group without these mutations, demonstrating excellent anticancer effects from low to high concentrations and confirming the anticancer effects of Saracatinib.

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Korea Institute of Science and Technology(KIST)

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