Illustration of stress buildup in stem cells. (IMAGE)

University of Tokyo

Illustration of stress buildup in stem cells.

Caption

This illustration shows that during heart failure, stress signals are transmitted to the brain, which then communicates through the nerves to the hematopoietic stem cells in the bone marrow, accumulating as stress memory. The stress-accumulated stem cells produce immune cells with reduced protective capabilities for organs such as the heart, kidneys, and muscles.

Credit

2024 Y. Nakayama, K. Fujiu, T. Oshima et al./ Science Immunology

Usage Restrictions

Credit must be given to the creator. No derivatives or adaptations of the work are permitted.

License

CC BY-ND

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