A proposed model of impaired autophagy in experimental acute pancreatitis induced by cerulein or alcohol. (IMAGE)

First Hospital of Jilin University

A proposed model of impaired autophagy in experimental acute pancreatitis induced by cerulein or alcohol.

Caption

Cerulein or alcohol impairs autophagy at multiple steps to promote pancreatitis. Cerulein or alcohol decreases pancreatic VMP1 to impair the closure of autophagosomes. Cerulein also decreases STX17 to impair the fusion of the autophagosome with a lysosome. Cerulein or alcohol decreases pancreatic TFEB, resulting in impaired lysosomal biogenesis and insufficient autophagy. Autophagy may selectively remove damaged mitochondria (mitophagy), abnormal ER (ER-phagy), leaky ZGs (zymophagy) and damaged lysosomes (lysophagy) to protect against acinar cell death and pancreatitis. ER, endoplasmic reticulum; STX17, syntaxin 17; TFEB, transcription factor EB; VMP1, vacuole membrane protein 1.

Credit

By Wen-Xing Ding, Xiaowen Ma, Sydney Kim, Shaogui Wang and Hong-Min Ni.

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Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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