Figure B：Hypothesis on the molecular mechanism underlying the mitigation of neurotoxicity by BNAP-AEO (IMAGE)

Tokyo Medical and Dental University

Figure B：Hypothesis on the molecular mechanism underlying the mitigation of neurotoxicity by BNAP-AEO

Caption

The conventional ASO inhibits the function of calcium channels in neurons, inducing a decrease in intracellular calcium ions and the manifestation of acute neurotoxicity (left). In contrast, the BNAP-AEO ASO prevents the reduction of intracellular calcium ion via the Sigma-1 receptor, potentially improving the induced toxicity (right).

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Department of Neurology and Neurological Science, TMDU

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