Rube Goldberg illustration (IMAGE)
Caption
A Rube Goldberg machine illustrates the studied immunotherapy pathway. The scissors represent the ARID1A mutation and its effect on chromatin structure. Birds with DNA tails flying away represent DNA leaving the nucleus into the cytosol. The falling balls represent the cGAS-STING and Type I Interferon pathways, which sound the alarm to trigger an immune response. Finally, arrows representing T cells are released at a target with a crab in its center, representing cancer.
Credit
Salk Institute
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Original content