Figure 3 (IMAGE)

The University of Hong Kong

Figure 3

Caption

Fig. 3. Simulation-assisted extraction of cellular forces from T1 mapping. (A) The schematics show the simplified model: a layer of NV centers is randomly distributed underneath the upper surface of diamond membrane with a given depth and fixed density; a layer of the Gd3+ complexes attached to the PEG acts as a randomly fluctuating spin bath; the aforementioned two layers are separated by spring-like PEG molecules and their force-induced extension is described by Worm-Like Chain model. The red rectangular area represents the minimum sensing area adopted (600 nm × 600 nm). (B) The simulated relationship between cellular forces and T1 value. The extracted (C) PEG extension map, and (D) cellular traction force map of cell body in one chosen cell (the same one in Fig. 6B). The insert is the enlarged view of selected rectangular area. (E) Force profile along the blue line drawn in Fig. 7D. The direction of the cellular force exerted on the PEG polymer is normal to the diamond surface.

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The University of Hong Kong

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