Kubo Keratosis Abstract (IMAGE)
Caption
To develop porokeratosis, people need two damaged copies of the gene, “two hits.” One they acquire either from their parents (left) or through epigenetic silencing early in their fetal development (middle and right). This predisposes them to developing the disease but in itself is not symptomatic. In the case of epigenetic silencing, individuals are mosaics of predisposed cells (green area), that derive from the one where the silencing occurred, and unaffected cells. A second defect in the other copy of the gene leads to the outbreak (red dots).
Credit
KUBO Akiharu
Usage Restrictions
Credit must be given to the creator.
License
CC BY