Pathogenesis in the MDA5-induced interstitial lung disease (IMAGE)

Tokyo Medical and Dental University

Pathogenesis in the MDA5-induced interstitial lung disease

Caption

Autoimmunity to MDA5, CD4 T cells reactive MDA5, works as 'Seed', and inducible factors like as virus infection and poly (I:C) treatment induce type I IFN upregulation and MDA5 expression on the lung and works as 'Soil'. The seed and soil work together to establish interstitial lung disease. IL-6 mediates lung fibrosis.

Credit

Department of Dermatology, TMDU

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